Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy
The IC50 values of the six representative NMs in different cellular systems calculated at different time points (24 to 72h or 10 days). The heat map shows a higher toxicity of ZnO NMs, followed by SiO2 and TiO2. The highest sensitivity after short term exposure to NMs was noted in the case of murine alveolar macrophages (MH-S) while Calu-3 were the most resistant cells. The long term exposure (10 days) of NIH3T3 and mES cells to NMs induced also significant cytotoxic effect.