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Heterogeneity of Synovial Molecular Patterns in Patients with Arthritis

Fig 4

Comparison of gene expression differences between samples from patients with OA, RA and SA, using high-density versus low-density microarrays.

Independent sets of samples were hybridized on high-density (HGU133 Plus 2.0 GeneChip) and low-density (DualChip) microarrays. (A) Differences in mean (log2-transformed) gene expression values between OA and (RA+SA) samples are displayed for the samples hybridized on high-density (x axis) versus low-density (y axis) arrays. (B) The same data from OA and (RA+SA) samples are displayed after normalization of each mean (log2-transformed) gene expression value by its standard deviation. (C) Normalized TCR gamma alternate reading frame protein (TARP), lymphocyte-specific protein tyrosine kinase (LCK) and Interleukin-7 Receptor (IL7R) gene expression data in OA versus RA and SA samples observed using low-density arrays. (D) Normalized Placental Growth Factor (PGF) gene expression data in OA versus RA and SA samples observed using low-density arrays. Mean values are represented by a horizontal bar. p values are calculated using Student’s t tests.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0122104.g004