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Down-Regulation of KCC2 Expression and Phosphorylation in Motoneurons, and Increases the Number of in Primary Afferent Projections to Motoneurons in Mice with Post-Stroke Spasticity

Figure 5

KCC2, S940 phosphorylation in KCC2, and NKCC1expression levels assessed by western blot analysis in membrane-enriched fractions of the ventral horn.

A, B, and C: At 3, 7, and 21 d post-stroke, bands of KCC2, phosphorylated S940, NKCC1, and tubulin. D-L: Quantification analysis of KCC2, phosphorylated S940, NKCC1levels at 3, 7, and 21 d after stroke. White bars are sham animals, and black bars are stroke animals. Data are presented as relative ratio to the mean sham non-affected and as the mean ± S.E.M. One-way ANOVA post hoc test Tukey-Kramer tests: *p<0.05, **p<0.01.

Figure 5