Down-Regulation of KCC2 Expression and Phosphorylation in Motoneurons, and Increases the Number of in Primary Afferent Projections to Motoneurons in Mice with Post-Stroke Spasticity
A: An illustration of the H reflex in the spinal cord circuit. The M wave is produced by orthodromically transmitting stimulation to motor fibers. The H reflex is a monosynaptic reflex that is transmitted via Ia afferent fibers. B and C: Evoked electromyograms measured in sham mice (B) and on the affected forelimb of stroke mice (C) at 7 d post-stroke. Repeated stimulation at high frequency (5 Hz) decreased the amplitude of the H reflex in sham mice (B). The amplitude of the H reflex on the affected forelimb of stroke mice was not decreased following 5 Hz stimulation (C).