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Role of Tissue Factor in Mycobacterium tuberculosis-Induced Inflammation and Disease Pathogenesis

Figure 7

Varied TF expression levels in macrophages derived from different sources in wild-type (WT), HTF and low TF mice in response to M.tb and LPS stimulation.

Macrophages (∼0.5×105 cells) were either stimulated with live M.tb (10 CFU/cell) or 10 µg/ml of gamma-irradiated M.tb (γ-M.tb) for overnight in antibiotic free RPMI complete medium. Macrophages were also stimulated with LPS (1 µg/ml) as a positive control for 6 h. At the end of the treatment, TF activity was measured in FX activation assay. * denotes significantly different from unstimulated controls. (* p<0.05; ** p≤0.001; *** p<0.0001) as obtained by Students t-test. Data are mean ± SEM (n = 6–17).

Figure 7

doi: https://doi.org/10.1371/journal.pone.0114141.g007