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The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells

Figure 9

ABCB-1/P-gp expression changes caused by 3-BrPA in vivo.

a: The mRNA level of ABCB-1 in MCF-7/ADR tumor tissue treated with different groups was determined by real-time PCR, β-actin served as internal controls for real-time PCR respectively. b, c: The protein expression level of P-gp in MCF-7/ADR tumor tissue treated with different groups was determined by Western blotting analysis, β-actin served as internal controls Western blotting, respectively. *P<0.05 compared with the control, **P<0.01 compared with the control.

Figure 9

doi: https://doi.org/10.1371/journal.pone.0112132.g009