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Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

Figure 11

Metabolic changes in the mutant NP.

In situ hybridization for PGK mRNA in the NP of control (HIF-1αf/f) (a,c) and mutant (Foxa2iCre;HIF-1αf/f) (b,d) mice at E15.5. Darkfield (a,b) and brightfield (c,d) pictures are shown. Bar = 50 µm.

Figure 11