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Muscle Atrophy in Response to Cytotoxic Chemotherapy Is Dependent on Intact Glucocorticoid Signaling in Skeletal Muscle

Figure 5

The Gene Expression Signature of Chemotherapy-Induced Cardiotoxicity Contains Glucocorticoid Dependent and Independent Elements.

GRLox/Lox and mGRKO mice (n = 6–13/group) were treated with CAF chemotherapy and sacrificed 18 hours later. (A, B, C, D) Heart gene expression was measured by quantitative real time PCR with GAPDH as an endogenous control. * = P<0.05, ** = P<0.01, and *** = P<0.001 vs. sham-treated mice of the same genotype as measured by two-way ANOVA with Bonferroni post-test. V = Vehicle, C = Chemotherapy.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0106489.g005