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Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells

Figure 1

Effects of HPV-16 oncoproteins on HIF-1α expression and PI3K/Akt/mTOR signaling pathway activation in NSCLC cells.

(A) Western blot analysis of HIF-1α protein levels in stable-transfected A549 cells. (B) Real-time PCR analysis of HIF-1α mRNA levels in stable-transfected A549 cells. (C and D) Western blot analysis of p-Akt, p-P70S6K, p-P85S6K, and p-mTOR protein levels in transfected A549 (C) and NCI-H460 (D) cells.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0103440.g001