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Exploring the Competition between Proliferative and Invasive Cancer Phenotypes in a Continuous Spatial Model

Figure 3

A map of the simulated tumor behavior regarding the dominant phenotypes as a function of the proliferation and diffusion rate of the invasive phenotype relative to phenotype 1 for A, B) the hypoxia-induced invasion (phenotype 2*) and C, D) the unconditional more invasive phenotype (phenotype 3*), under poor and well vascularized conditions, respectively.

Points with blue color correspond to parametric pairs where the proliferative phenotype 1 dominates. With red color is represented the dominance of the invasive phenotype and with green color is depicted the region where a transition from the dominance of the proliferative phenotype 1 to the dominance of the invasive phenotype is observed.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0103191.g003