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Plasma Membrane Proteomics of Human Breast Cancer Cell Lines Identifies Potential Targets for Breast Cancer Diagnosis and Treatment

Figure 1

Workflow outlines process of obtaining plasma membrane proteome of multiple BC cell lines.

After establishing an effective method for isolating plasma membrane proteins, representatives from each of the currently defined classes of BC were cultured and plasma membranes were isolated and subjected to MS, yielding a comprehensive list of protein identifications having an FDR ≤1%. These data were biologically validated and the data were mined for relevant protein candidates.

Figure 1