Local Over-Expression of VEGF-DΔNΔC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis
Figure 3
Vascular reactivity of uterine arteries 30–45 days after vector administration.
(A) Logarithmic dose-response curve to L-phenylephrine (PE) depicting that the contractile tension generated in the UtAs of term pregnant sheep (n = 5) is significantly lower in Ad.VEGF-DΔNΔC transduced vessels relative to Ad.LacZ transduced vessels 30–45 days post-injection. The contractility of the vessel is expressed as a percentage of the response to KCl. * p<0.005. (B) Logarithmic dose-response curve to Bradykinin (BK) depicting that the relaxation response generated in the UtAs of term pregnant sheep (n = 5) is not significantly different between the Ad.VEGF-DΔNΔC and Ad.LacZ treated vessels 30–45 days post-injection. The relaxation is expressed as a percentage of inhibition of PE-induced contractions. Error bars denote SEM.