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Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells

Figure 4

Effects of AhR siRNA on Mas receptor and peNOS expression in HK-2 cells.

HK-2 cells were treated with or without AhR siRNA (siAhR, 30 nM) (A). Knockdown of AhR inhibited IS-induced downregulation of Mas receptor (B) and peNOS (C) expression. Data are means±SE, expressed as relative change in comparison with the basal value (n≥3 for every experiment). *p<0.05 vs. control; #p<0.05 vs. IS.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0091517.g004