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MIR376A Is a Regulator of Starvation-Induced Autophagy

Figure 7

Endogenous MIR376A limits starvation-induced autophagy.

(A) Blockage of endogenous MIR376A by Ant-376a, but not CNT-Ant further stimulated starvation (STV)-activated LC3-I to LC3-II conversion in MCF-7 cells. ACTB was used as a loading control. LC3-II/LC3-I densitometric ratios were marked. (B) Ant-376a, but not CNT-Ant resulted in further activation of SQSTM1 protein degradation following starvation in MCF-7 cells. SQSTM1/ACTB ratios were marked.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0082556.g007