A Prognostic Gene Signature for Metastasis-Free Survival of Triple Negative Breast Cancer Patients
The proliferation signature was used to categorize breast tumors into (A) ER-HER2- (15 BPMS+ patients out of 121 ER-HER- patients, χ2 = 10.5), (B) TNBC (18 BPMS+ patients out of 118 TNBC patients, χ2 = 9.4), (C) ER+HER2- (n = 1), and (D) HER2+ (8 BPMS+ patients out of 117 HER2 patients, χ2 = 0). BrCa443 patients were stratified for MFS using the BPMS. Red indicates patient tumors that express the BPMS signature while black indicates patient tumors that do not. Survival curves were generated by Kaplan–Meier analysis, and the indicated P-values were calculated by the log-rank test.