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Dysregulation of Anti-Inflammatory Annexin A1 Expression in Progressive Crohns Disease

Figure 7

Proposed mechanism.

The gut in an IBD patient is affected by the interplay of several factors including host microbe interactions, immune system defects/hyperactivity and dysfunctional epithelium. The loss or down regulation of Annexin A1 at the epithelial surface contributes to the epithelial dysfunction and immune modulation allowing for increased microbial translocation and increased inflammation despite IFX therapy. In positive regulators an increase in ANXA1 expression may improve control of inflammation with a reduction in symptoms.

Figure 7