Canine Chondrodysplasia Caused by a Truncating Mutation in Collagen-Binding Integrin Alpha Subunit 10
Figure 3
Chondrodysplasia pedigrees are consistent with autosomal recessive inheritance.
(A) A pedigree established around the affected Norwegian Elkhounds from Finland. Samples and phenotype information were obtained from all siblings in one litter only, otherwise the phenotypes of full siblings of affected dogs were not known. Denoted are the nine cases and controls that were genotyped using the canine SNP-chip. (B) A pedigree drawn around four affected Norwegian Elkhounds from the United States. (C) A pedigree of the chondrodysplasia phenotype in Karelian Bear Dogs. All affected Karelian Bear Dogs have a single popular sire as a common ancestor (arrow). In all three pedigrees, the recessive c.2083C>T mutation shows full segregation with the chondrodysplasia phenotype. Genotypes are marked with red (T/T), blue (C/T) and black (C/C).