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Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats

Figure 5

Effect of intraperitoneal (IP) administration of Wy-14643 on the protein expression pattern.

Carnitine palmitoyltransferase 1A (CPT 1A) (top), mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoAS2) (bottom) and β-actin in the liver (A), the duodenum (B) and the jejunum (C) were analyzed by Western blotting 1h after IP administration of Wy-14643 (40 mg/kg/ml). Panels below the graphs show representative blots; upper panels show quantification of protein levels after normalization to β-actin. Data are presented relative to the vehicle (100%) and each bar represent median with 25th/75th percentiles (* P<0.05; Mann-Whitney U test).

Figure 5