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Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats

Figure 4

Effect of intraperitoneal (IP) administration of Wy-14643 on energy homeostasis.

Respiratory quotient (A), spontaneous locomotor activity (B), energy expenditure and body temperature (C, D) were assessed during 12 h following IP administration of Wy-14643 (40 mg/kg/ml). * and** significantly different from vehicle (*P < 0.05, **P < 0.01; Wilcoxon Signed Ranks Test, data presented as median with 25th/75th percentiles.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0074869.g004