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Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats

Figure 3

Effects of intraperitoneal (IP) administration of Wy-14643 on plasma metabolites.

β-hydroxybutyrate (BHB) (A) and non-esterified fatty acids (NEFA) (B) levels were assessed 45 min before (baseline), 35 and 70 min after treatment (Wy-14643, 40 mg/kg/ml) and 3g HFD test meal. ** Significant difference compared to vehicle (P < 0.01; Wilcoxon Signed Ranks Test, data are presented as median with 25th/75th percentiles.

Figure 3