Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats
IP administered Wy-14643 (40 mg/kg/ml) on meal patterns in ad libitum HFD-fed rats (n = 23). Wy-14643 increased the latency of the first meal (A) and decreased the second meal size (E), but did not significantly affect first meal size and duration (B, C), intermeal interval (D) and second meal duration (F). Data for first meal size are presented as median with percentiles and were analyzed with Wilcoxon Signed Ranks Test. Results for the other parameters (latency to eat, first meal duration, second meal size and duration) are presented as means ± SEM and were analyzed using a paired t-test. ** Significant difference (P < 0.01) compared to vehicle.