Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart
Xaliproden caused a significant increase in deposition of collagen types I (A) and III (B) at 2 weeks and at 12 weeks and a significant increase in the number of MPO positive cells (C) at 12 weeks after small intestine irradiation. Average ± SEM, n = 5–15. *p<0.05, †p<0.001. Representative micrographs of immunohistochemical stainings are shown in Figure S4 and S5.