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Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart

Figure 7

Immunohistochemical analysis of collagen deposition and MPO positive cells in radiation enteropathy.

Xaliproden caused a significant increase in deposition of collagen types I (A) and III (B) at 2 weeks and at 12 weeks and a significant increase in the number of MPO positive cells (C) at 12 weeks after small intestine irradiation. Average ± SEM, n = 5–15. *p<0.05, p<0.001. Representative micrographs of immunohistochemical stainings are shown in Figure S4 and S5.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0070479.g007