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Nodes Having a Major Influence to Break Cooperation Define a Novel Centrality Measure: Game Centrality

Figure 2

Game centralities of E. coli methionyl-tRNA synthetase amino acids.

The protein structure network of E. coli methionyl-tRNA-synthetase was constructed, prisoner’s dilemma game was simulated, and game centrality measures were calculated as described in Methods. Game centralities were overlaid to the 3D image of the protein and tRNA made by the PyMOL program package [66]. tRNAMet is shown in green, the most influential amino acids spreading defection are marked red (these amino acids have the largest game centrality, GC values) and the least influential amino acids are blue (having the smallest GC values).

Figure 2