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Nodes Having a Major Influence to Break Cooperation Define a Novel Centrality Measure: Game Centrality

Figure 1

Functional analysis of yeast proteins having the largest game centralities.

Prisoner’s dilemma game was simulated on a high-fidelity yeast interactome [36], and game centrality measures were calculated as described in Methods. 171 proteins out of the 2,444 nodes of the high-fidelity yeast interactome were selected by selecting nodes, which diminished the cooperation level from ∼1 to 0.9 or below. Functional analysis of the 171 proteins was performed using the Cytoscape plug-in, BiNGO [63] to assess the over-representation of associated Gene Ontology molecular function terms. Gene Ontology Slim definitions for Saccharomyces cerevisiae [64] were used discarding the evidence codes IEA (inferred from electronic annotation), ISS (inferred from sequence structural similarity) and NAS (non-traceable author statement). A hypergeometric test with false discovery rate correction [65] was used to select and visualize the significantly enriched GO functions at a level p<0.001, using the GO-s of the entire network as reference set. Colors represent functional categories: red, nucleus-related; blue, transport-related; green, signaling-related; yellow denotes other functions. The size of the circles represents the number of proteins found in the category.

Figure 1