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Trends in the Prevalence of Tuberous Sclerosis Complex Manifestations: An Epidemiological Study of 166 Japanese Patients

Figure 6

Trends in the age-specific frequency of each skin manifestation.

The frequency indicates the proportion of patients in each age group with A) FA (facial angiofibromas: blue), B) severe and mild FA (light blue), C) hypomelanotic macules (yellow), D) shagreen patches (purple) and E) ungual fibromas (red). The angiofibromas were divided into three classes, slight, mild and severe, as described in the text. AF includes angiofibromas of all classes. The bars indicate the CI.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0063910.g006