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Imperfect Duplicate Insertions Type of Mutations in Plasmepsin V Modulates Binding Properties of PEXEL Motifs of Export Proteins in Indian Plasmodium vivax

Figure 4

Structural cartoon representations of model of plasmepsin-V of P. vivax.

(A) Complete model with C-terminal trans-membrane domain (purple), the n-terminal pro-domain (lime) inhibiting the complete active site cleft with aspartic acid residue (red) and side chains. (B) Displaying structural changes after the cleavage of c-terminal trans-membrane domain (purple). The N-terminal prodomain peptide (lime) frees complete active site cleft after folding at hinge and competitively interacts with same amino acid residue side chains of the model as that of C-terminal in the native structure.

Figure 4