Imperfect Duplicate Insertions Type of Mutations in Plasmepsin V Modulates Binding Properties of PEXEL Motifs of Export Proteins in Indian Plasmodium vivax
Figure 4
Structural cartoon representations of model of plasmepsin-V of P. vivax.
(A) Complete model with C-terminal trans-membrane domain (purple), the n-terminal pro-domain (lime) inhibiting the complete active site cleft with aspartic acid residue (red) and side chains. (B) Displaying structural changes after the cleavage of c-terminal trans-membrane domain (purple). The N-terminal prodomain peptide (lime) frees complete active site cleft after folding at hinge and competitively interacts with same amino acid residue side chains of the model as that of C-terminal in the native structure.