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canEvolve: A Web Portal for Integrative Oncogenomics

Figure 7

Modeling of multiple myeloma evolution.

Identification of transcription factors and miRNAs whose target genes significantly change their overall expression compared to normal plasma cells during the evolution of myeloma from MGUS to relapsed stages by gene set enrichment analysis. The X-axis shows different evolutionary stages of myeloma. The Y-axis shows the –log10 (p-value) from the gene set enrichment analysis using the target genes of a TF or a miRNA based on MSigDB.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0056228.g007