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canEvolve: A Web Portal for Integrative Oncogenomics

Figure 5

dChip-GemiNI analysis integrating gene expression with miRNA expression.

The summary bubble-bar plot from GemiNI analysis using the lung cancer dataset GSE18805 to identifies candidate transcription factors, miRNAs, and TF-miRNA feed-forward loops (FFL) involved in cancer pathogenesis. TFs and miRNAs are ranked by the percentage of normal-cancer differentially expressed genes explained by all the significant FFLs involving a TF or miRNA (the height of bars). The top 20 TFs and miRNAs are displayed. The bubble size indicates the number of differentially expressed FFL target genes, and color indicates the FFL significance. For more details on the figure and the methodology see [28].

Figure 5

doi: https://doi.org/10.1371/journal.pone.0056228.g005