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Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine

Figure 12

Anatabine prevents demyelination in the spinal cord of EAE mice.

Representative 40X microscopic fields of longitudinal sections of the spinal cord from control, EAE placebo and EAE anatabine treated mice stained with Luxol fast blue are shown. The histogram represents the average Luxol fast blue burden observed in the spinal cord of control, EAE placebo and EAE anatabine treated mice. ANOVA reveals a significant main effect of EAE (P<0.001) and of anatabine (P<0.001) on Luxol fast blue burden in the spinal cord. Post-hoc comparisons show statistically significant differences for the average Luxol fast blue burden between control and EAE placebo mice (P<0.001) and between EAE placebo and EAE anatabine treated mice (P<0.001).

Figure 12

doi: https://doi.org/10.1371/journal.pone.0055392.g012