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Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Figure 5

Systemic immunological abnormalities in Ctip2ep−/− adult mice.

Serum concentration of (A) IL4, (B) IL13, (C) CCL17, (D) TSLP, (E) TNFα and (F) IgE was measured by ELISA. (G) Gross morphological comparison of spleen, lymph node (LN) and liver in 4-months-old WT and Ctip2ep−/− mice. (H) Spleen weight of WT and Ctip2ep−/− mice at different months of age is indicated. Statistical analyses were performed by student's unpaired t-test using GraphPad Prism software; * P<0.05, ** P<0.01, *** P<0.005.

Figure 5