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Diagnostic Peptide Discovery: Prioritization of Pathogen Diagnostic Markers Using Multiple Features

Figure 1

Visualization of peptide-score profiles generated by the method.

A) the 60S ribosomal protein L19 (locus identifier TcCLB.509149.40), and B) a putative lectin (locus TcCLB.506239.30). These plots display peptide scores and features along protein sequences. Mapped features in these examples are those listed in Table 1: antigenicity (Bepipred), protein disorder, internal repeats, signal peptide, signal peptide cleavage site, non-synonymous polymorphisms, high conservation vs human, high conservation vs Leishmania spp, low sequence complexity, glycosylated threonines, cysteines, and presence of domain absent in orthologous proteins (NC DOMAIN). Vertical boxes represent overlapped 12-residue peptides, and their height and level of green are proportional to the peptide score. They vary around their base protein scores (i.e. 4.7 and 5.5), which accounts for subcellular localization and expression.

Figure 1