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Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Figure 4

Cibacron blue and Aβ fibril fractionated NAbs binding to amyloidogenic conformers.

Antibody binding curves were generated for unfractionated IVIg, Cibacron blue-isolated and depleted, and for Aβ fibril-isolated IVIg IgGs against plate-immobilized Aβ fibrils (A), CAPS (B), Aβ monomers (C), And LC fibrils (D). The data symbols in Panels A to D represent Aβ conformer binding by antibody preparations as specified in the legend of Panel A.

Figure 4