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DNA-Interactive Properties of Crotamine, a Cell-Penetrating Polypeptide and a Potential Drug Carrier

Figure 9

Binding of d(CCG)8C to Arg-Trp-Arg-Trp-Lys-Leu-NH2 as a function of [NaCl].

A. Fluorescence titrations were performed as in Fig. 3, with the following [NaCl]: ▪, 0.01 M; ♦, 0.05 M; □, 0.075 M; ▴, 0.1 M. B. NaCl reversal: ▪, reversal of 0.01 M titration of Arg-Trp-Arg-Trp-Lys-Leu-NH2 with d(CCG)8C; ◯, reversal of 0.01 titration of crotamine with d(CCG)8C (data from Fig. 3B).

Figure 9