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DNA-Interactive Properties of Crotamine, a Cell-Penetrating Polypeptide and a Potential Drug Carrier

Figure 8

Possible model for crotamine – double stranded DNA major groove interaction.

Crotamine (1h50.pdb) and DNA (1bna.pdb) were generated using Rasmol. [46] Sidechains of potentially interacting arginine and tryptophan residues are indicated. The locations of the six lysine ε-NH2 groups visible in the pictured orientation are indicated by circles.

Figure 8