Interactome-Wide Prediction of Protein-Protein Binding Sites Reveals Effects of Protein Sequence Variation in Arabidopsis thaliana
Distributions of sequence identity values are shown for paralogous pairs classified as having “no” (red), “low” (black) or “high” (blue) functional divergence. The x-axis represents the sequence identity of paralogous pairs. For each paralogous pair, the sequence identity was calculated using either (A) the whole protein sequences, or (B) just the sequence of predicted binding sites. The better separation between the curves for no functional divergence vs. high functional divergence when using predicted interaction sites indicates that these contain signal related to functional divergence.