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Predicting the Functional Effect of Amino Acid Substitutions and Indels

Figure 9

Number of supporting sequences used for the Uniprot human proteins carrying neutral or deleterious variants.

(A) Distribution of the 11,990 human proteins based on the number of supporting sequences used for PROVEAN prediction. (B) Prediction accuracy achieved with respect to the number of supporting sequences. The observed accuracy is consistently above 73%, except in cases when the number of supporting sequences drops below 50.

Figure 9

doi: https://doi.org/10.1371/journal.pone.0046688.g009