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Predicting the Functional Effect of Amino Acid Substitutions and Indels

Figure 7

PROVEAN score distribution of TP53 variations binned into 15 classes based on transactivation levels.

For each class, a box plot is shown. The vertical line shows the whole range of delta scores, the thick horizontal line shows the median, and the gray rectangle shows the interquartile range (25%–75%). The PROVEAN score increases and correlates with median transactivation level for the non-functional and partially functional classes of variations.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0046688.g007