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Predicting the Functional Effect of Amino Acid Substitutions and Indels

Figure 6

ROC curves of different prediction tools for single amino acid substitutions in (A) E. coli lac repressor protein and (B) human TP53 tumor suppressor protein.

The AUC values are shown in the legend. The top two performers for LacI were PolyPhen-2 and PROVEAN, and those for TP53 were Mutation Assessor and PROVEAN.

Figure 6