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Predicting the Functional Effect of Amino Acid Substitutions and Indels

Figure 4

PROVEAN score distribution of deletions and insertions collected from the Human Gene Mutation Database (HGMD) and the 1000 Genomes Project.

Only mutations annotated as “disease-causing” were collected from the HGMD. The distribution shows a distinct separation between the two datasets.

doi: https://doi.org/10.1371/journal.pone.0046688.g004