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Transcriptome Tomography for Brain Analysis in the Web-Accessible Anatomical Space

Figure 5

Expression densities of Huntington’s disease related genes in the brain areas defined by area-marker gene expression.

(A) Quantified expression variances of Htt, related to differential vulnerability in the disease. 3D expression maps of Htt are highlighted in areas (with arrows) defined by the expression of area-marker genes (named at the bottom of the panels), which are known to be expressed in the anatomical regions or the cell types (named at the top). Percentages of Htt expression densities (100% in the motor CTX) and the vulnerability of the areas in Huntington’s disease are indicated below the panels. *: significantly lower compared to motor CTX (p = 10−5–10−41), **: selective cells are partly affected [21],[23]. (B) Expression variances of Bdnf related to the vulnerability of the disease. 3D expression maps of Bdnf in the areas defined by the expression of area maker genes as indicated are shown along with the vulnerability of the areas. (C) Expression maps of Htt in brain areas defined by Bdnf expression. The maps, a percentage of Htt expression densities and the vulnerability of the areas are visualized in the same way as in A. An Arrow indicates high expression of Htt, and Bdnf in the posterior cerebrum. Abbreviations for neural cell types: GABA: GABAergic, Ach: Acetyl-cholinergic, DA: dopaminergic, 5HT: serotonergic, NAd: noradrenalinergic. Abbreviations for brain regions: CA: Ammon’s Horn, CB: cerebellum, CPu: caudate putamen, CTX: cerebral cortex, Hipp: hippocampus, DG: dentate gyrus, SN: substantia nigra, VTA: ventral tegmental area, Tg: dorsal tegmental nucleus.

Figure 5