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NR4A1 (Nur77) Mediates Thyrotropin-Releasing Hormone-Induced Stimulation of Transcription of the Thyrotropin β Gene: Analysis of TRH Knockout Mice

Figure 9

Proposed models of the TRH-NR4A1-TSHβ pathway.

TRH stimulates the transcription of the NR4A1 gene through TRH receptors, and PKC and MAPK pathways within 1 hr. The increased amount of NR4A1 stimulates TSHβ promoter activity, which may act cooperatively with Pit1 and GATA2 on the gene.

Figure 9