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Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Figure 2

Ursolic acid increases exercise capacity, does not alter blood pressure, and reduces resting heart rate in high fat-fed mice.

Mice were fed high fat diet (HFD) lacking or containing 0.27% ursolic acid (UA) for 17 weeks, and then exercise treadmill capacity was determined according to an established protocol [36] (A) and resting blood pressure and heart rate were determined with tail cuff plethysmography (B and C). Data are means ± SEM from ≥7 mice per diet. P-values were determined with t-tests. *P<0.05.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0039332.g002