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Leukemia Gene Atlas – A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

Figure 4

The role of RUNX1 and its binding sites in leukemias.

(A) Screenshot of a t-test result table with the 33 most differentially expressed genes with RUNX1 binding sites in progenitor and non-progenitor cells. (B) Distribution of RUNX1 expression for different leukemic disease states. (C) Heat map and hierarchical clustering of patients with acute lymphoblastic leukemia and non-leukemia samples with healthy bone marrows for gene expression of genes with RUNX1 binding sites and highest variances over all samples. The phenotype color grid at the top represents the sample characteristics. (D) Kaplan Meier curves of event-free survival for patients with acute myeloid leukemia with low (≤33% quantile), median (>33% quantile and ≤66% quantile), and high RUNX1 expression (>66% quantile).

Figure 4

doi: https://doi.org/10.1371/journal.pone.0039148.g004