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How to Minimize the Attack Rate during Multiple Influenza Outbreaks in a Heterogeneous Population

Figure 8

Cumulative attack rates against the start day of intervention in the presence of inter-group transmission.

Transmission between adults and children was 1% of intra-group transmission (βAC = 0.01 * βAA; βCA = 0.01 * βCC; upper row), or 10% (βAC = 0.1 * βAA; βCA = 0.1 * βCC; middle row), or 100% (βAC = βAA; βCA = βCC; lower row). The fraction of adults in the population was (from left to right) 10%, 30%, 50%, 70%, and 90%. Black dotted line: adults (CAAA); grey broken line: children (CACC); red solid line: whole population (CAW). Like the no-coupling scenario, the CAW curve shifted lower if there were more adults and higher if there were more children. In the lower panels, all three lines overlap with each other. R0A = 1.25, R0C = 2; 50% adults; 50% children; long intervention; interrupt all routes of transmission; intervention efficacy, fAA = fAC = fCA = fCC = 1. All other parameters and initial conditions are listed in Tables 1 and 2.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0036573.g008