Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
Representative photomicrographs of lung tissue two days after challenge of Balb/c and C57BL/6 mice that had previously been given a SARS-CoV vaccine. Lung sections were separately stained with H&E (pink and blue micrographs) or the immunohistochemical stain for eosinophil major basic protein (blue and brown micrographs). Balb/c mice lung sections are in the left column and C57BL/6 are in the right column; doubly inactivated whole virus vaccine is in the upper four panels and those from mice given the β propiolactone inactivated whole virus vaccine are in the lower four panels. Pathologic changes observed (inflammatory infiltrates) are similar in Balb/c and C57BL/6 and eosinophils are prominent in both groups.