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Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Figure 8

Mouse and Vaccine Specificity, Experiment 3.

Mean lung cellular infiltration/lesion pathology and percent eosinophils in infiltrates for each vaccine dosage group for each mouse strain (Balb/c or C57BL/6) two days after challenge with SARS-CoV. A. Mean lesion score and standard error of the mean (S.E.) for each vaccine dosage group. Scores are mean of scores for seven to eight mice per group. Scoring 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiole and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen. Ten to 20 microscopy fields were scored for each mouse lung. B. Mean score and standard error of the mean (S.E.) for eosinophils as percent of infiltrating cells for each vaccine dosage group. Scores are mean of scores for seven to eight mice per group. Scoring: 0 - <5% of cells, 1 - 5–10% of cells, 2 - 10–20% of cells, 3 - >20% of cells. Ten to 20 microscopy fields were scored for each mouse lung. Analyses: A. Mean lesion scores were not different p>.05. B. Mean eosinophil scores were different p<.001. Mean scores for vaccine groups greater than non-vaccine groups for Balb/c and C57BL/6 p<.001 for all comparisons. Mean eosinophil scores for the same groups not different for Balb/c and C57BL/6 p>.05.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0035421.g008