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Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Figure 4

Higher Dosages of SV Vaccine plus DIV and BPV Vaccine Comparisons, Experiment 2.

Mean lung cellular infiltration/lesion pathology and mean percent eosinophils in infiltrates for each vaccine dosage group two days after challenge with SARS-CoV. A. Mean lesion score and standard error of the mean (S.E.) for each vaccine dosage group. Scores are mean of scores for seven to eight mice per group. Scoring - 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiolar and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen. Ten to 20 microscopy fields were scored for each mouse lung. B. Mean score and standard error of the mean (S.E.) for eosinophils as percent of infiltrating cells for each vaccine dosage group. Scores are mean of scores for seven to eight mice per group. Scoring: 0 - <5% of cells, 1 - 5–10% of cells, 2 - 10–20% of cells, 3 - >20% of cells. Ten to 20 microscopy fields were scored for each mouse lung. Analyses: A. Mean lesion scores were different p<.001. Mean scores were lower for SV than DIV p<.001 and less than BPV p = .006. B. Mean eosinophil scores were lower for SV than DIV p<.001 and less than BPV p<.001. Eosinophil scores greater for SV than PBS or live virus p<.001.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0035421.g004