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Visualization and Curve-Parameter Estimation Strategies for Efficient Exploration of Phenotype Microarray Kinetics

Figure 8

Results from an archetype analysis of the four parameters estimated from the PM curves obtained from the 1st and the 2nd dataset using the smoothing splines.

The outer figure is a scree plot in which the residual sums of squares (RSS, y-axis) are plotted against the corresponding predefined numbers of archetypes (x-axis). Apparently either four or five archetypes are optimal according to the “elbow criterion”. The insert (upper right) is a parallel coordinates plot showing the original measurements (gray lines) as well as the optimal archetypes (green, black, blue, violet and red lines) obtained if five archetypes are requested. On the x-axis, the names of the curve parameters are indicated. The minima and maxima of the four y-axes are also indicated. For an interpretation of the archetypes, see the main text.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0034846.g008