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Visualization and Curve-Parameter Estimation Strategies for Efficient Exploration of Phenotype Microarray Kinetics

Figure 3

Comparison of parameter and CI estimates from the same curves using three distinct approaches.

Left, enlarged view of the curves from wells G11 and H11 as depicted in Fig. 2. As in Fig. 2, the affiliation to each strain is indicated by color as follows: black, E. coli DSM 18039; red, E. coli DSM 30038T; green, P. aeruginosa DSM 1707; blue, P. aeruginosa 429SC. Right, point estimates and 95% CIs for each of the four parameters lag phase (λ), slope (µ), maximum (A) and area under the curve (AUC) estimated from the eight curves depicted on the left using either the model-fitting (blue dots and CIs) or the spline approach (red dots and CIs). The gray stars are the respective point estimators inferred with the native OmniLog® software (which does not provide CIs). The colored circular areas refer to the colors of the curves in the left part of the figure.

Figure 3