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Rescue of a H3N2 Influenza Virus Containing a Deficient Neuraminidase Protein by a Hemagglutinin with a Low Receptor-Binding Affinity

Figure 1

Affinities of the HAs of the H3NA- viruses for sialylglycopolymers.

Binding curves were fitted with the two models MM and MM2 for A/Moscow/10/99, A/Lyon-CHU/26430/03 and A/Reunion/586/04 viruses with 6′SLN receptors (A) and 3′SL receptors (B). The values of the dissociation constant (Kd) of the three viruses for 6′SLN receptors (C) and 3′SL receptors (D) calculated from the two models (MM and MM2) are indicated. The values correspond to the mean +/– standard deviation calculated from three independent assays. The Bayesian Information Criterion (BIC) is indicated for each regression.

Figure 1